BDBM1283 3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::3-{[1,3-benzoxazol-2-yl)-methyl]amino}-5-ethyl-6-methylpyridin-2(1H)-one::CHEMBL415320::L-696,040::Pyridinone deriv.

SMILES CCc1cc(NCc2nc3ccccc3o2)c(=O)[nH]c1C

InChI Key InChIKey=HXVYWXSMFWAGFQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 1283   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1283(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Affinity DataIC50:  210nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1283(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Affinity DataIC50:  210nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Merck Reserch Laboratories

Curated by ChEMBL
LigandPNGBDBM1283(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Affinity DataIC50:  210nMAssay Description:Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Merck Reserch Laboratories

Curated by ChEMBL
LigandPNGBDBM1283(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Affinity DataIC50:  209nMAssay Description:Inhibition of HIV-1 reverse transcriptase (HIV-1 RT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1283(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Affinity DataIC50:  210nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed