BDBM13246 5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3-thiazole-2,5-diamido::BMS-354825 2-Carboxamido-4-hydrido-thiazole Analog 7n::CHEMBL131577::N-(2-chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-1,3-thiazole-5-carboxamide

SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1

InChI Key InChIKey=CQZZCFVTEOJWAW-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 13246   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  35nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  71nMAssay Description:Inhibition of Fyn kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Hck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of KDR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  44nMAssay Description:Inhibition of Jak3 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of FAK kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CDK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of HER2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity of the compound against HER1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Lck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of FGF receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  880nMAssay Description:Inhibition of CD3/CD28 T-cell proliferation assay in PBL (peripheral blood lymphocytes)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed