BDBM13337 3-(benzyloxy)pyridin-2-amine::EN300-247019::Pyridine derived fragment based inhibitor 1

SMILES Nc1ncccc1OCc1ccccc1

InChI Key InChIKey=NMCBWICNRJLKKM-UHFFFAOYSA-N

Data  6 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 13337   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  1.30E+6nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  6.19E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  3.08E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  2.00E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astex

LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  1.30E+6nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataKd:  6.92E+5nMAssay Description:Binding affinity to Bcl-xL by 2D- NOESY analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed