BDBM13951 2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid::2-[(2,3-dimethylphenyl)amidoformic acid]benzoic acid::CHEMBL65459::diaryloxamic acid 1::oxalyl-aryl-amino benzoic acid-based inhibitor 1

SMILES Cc1cccc(N(C(=O)C(O)=O)c2ccccc2C(O)=O)c1C

InChI Key InChIKey=LTLAECLFZXWEMD-UHFFFAOYSA-N

Data  5 KI  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 13951   

TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13951(2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | ...)
Affinity DataKi:  9.30E+4nM ΔG°:  -5.44kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13951(2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | ...)
Affinity DataKi:  9.30E+4nM ΔG°:  -5.44kcal/mole Kd:  1.24E+5nMpH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13951(2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | ...)
Affinity DataKi:  1.64E+5nM ΔG°:  -5.11kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13951(2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | ...)
Affinity DataKi:  2.93E+5nMAssay Description:Binding affinity for Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13951(2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | ...)
Affinity DataKi:  2.93E+5nM ΔG°:  -4.77kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13951(2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | ...)
Affinity DataKd:  1.00E+5nMAssay Description:Dissociation constant for Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13951(2-[(2,3-Dimethylphenyl)oxalylamino]benzoic acid | ...)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to N-terminal GST-fused human PTP1B (1 to 288 residues) expressed in Escherichia coli BL21(DE3) by HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed