BDBM14191 N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4-(2-methoxyethyl)piperazin-1-amine::pyrrolopyrimidine 14

SMILES COCCN1CCN(CC1)Nc1ncc2ccn(C3CCCCC3)c2n1

InChI Key InChIKey=VDNDJYFLOAXKKR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14191   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14191(N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4...)
Affinity DataIC50:  110nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 795 of Rb by purified recombinant CDK4. The phosphorylation of s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14191(N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed