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BDBM143295 US9682953, 5.1

SMILES: CN(C)c1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1

InChI Key: InChIKey=YGDKETJVBNSVPP-JXAWBTAJSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 143295   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty-acid amide hydrolase 1


(Rattus norvegicus (rat))
BDBM143295
PNG
(US9682953, 5.1)
Show SMILES CN(C)c1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N4O2/c1-34(2)24-12-8-20(16-31-24)26(35)33-22-10-6-18(7-11-22)14-19-4-3-5-23(15-19)36-25-13-9-21(17-32-25)27(28,29)30/h3-5,8-9,12-17,22H,6-7,10-11H2,1-2H3,(H,33,35)/b18-14-
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/a7.425



Advinus Therapeutics Ltd

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM143295
PNG
(US9682953, 5.1)
Show SMILES CN(C)c1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N4O2/c1-34(2)24-12-8-20(16-31-24)26(35)33-22-10-6-18(7-11-22)14-19-4-3-5-23(15-19)36-25-13-9-21(17-32-25)27(28,29)30/h3-5,8-9,12-17,22H,6-7,10-11H2,1-2H3,(H,33,35)/b18-14-
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/a7.425



Advinus Therapeutics Ltd

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair