BDBM143781 US10183953, Example 42::US8969352, 42::US9611277, Example 42::US9845333, 42

SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1

InChI Key

Data  18 KI

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 143781   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  175nM ΔG°:  -8.56kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM 001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  175nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  175nMAssay Description:CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  175nMAssay Description:CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  175nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  175nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  184nMAssay Description:Rat and Human Orexin 1 Receptor:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_00152...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  184nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  184nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  184nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  184nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  184nM ΔG°:  -8.54kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM 001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  5.80E+3nMAssay Description:Human Orexin 2 Receptor:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hycl...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  5.80E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  5.80E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  5.80E+3nMAssay Description:PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1 pen-strep...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  5.80E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM143781(US10183953, Example 42 | US8969352, 42 | US9611277...)
Show SMILES FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1
Affinity DataKi:  5.80E+3nMAssay Description:PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1 pen-strep...More data for this Ligand-Target Pair