BDBM14675 CHEMBL26128::Fragment 5::Phenylphosphate::phenoxyphosphonic acid

SMILES OP(O)(=O)Oc1ccccc1

InChI Key InChIKey=CMPQUABWPXYYSH-UHFFFAOYSA-N

Data  5 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14675   

TargetProto-oncogene tyrosine-protein kinase Src [145-252](Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM14675(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Affinity DataIC50:  3.50E+6nMpH: 7.4 T: 2°CAssay Description:SPA uses 125I as energy donor and scintillant-coated beads as energy acceptor. The labeled ligand is captured by the biotinylated Src-SH2 protein imm...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Affinity DataIC50:  5.00E+6nMAssay Description:Binding affinity for Src protein tryrosine kinase SH2 domain using surface plasmon resonance (SPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
The University Of Birmingham

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Affinity DataIC50:  3.25E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Affinity DataIC50:  3.00E+5nMAssay Description:Binding affinity for Src protein tryrosine kinase SH2 domainusing scintillation proximity binding assay (SPA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Affinity DataIC50:  2.50E+6nMAssay Description:The compound was evaluated for its binding affinity towards phosphotyrosine binding pocket of Src protein tryrosine kinase SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity against Lck SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed