BDBM14739 (R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)-pyrrolidin-1-yl]-quinazoline::6,7-Dimethoxy-4-pyrrolidylquinazoline 2::6,7-dimethoxy-4-[(3R)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]quinazoline

SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C(F)(F)F)c2cc1OC

InChI Key InChIKey=JRTNNOOVINPMKT-CYBMUJFWSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14739   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi: >100nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi:  811nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14739((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Affinity DataKi:  811nM ΔG°:  -8.22kcal/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed