BDBM14758 (R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidin-1-yl]-quinazoline::6,7-Dimethoxy-4-pyrrolidylquinazoline 19::6,7-dimethoxy-4-[(3R)-3-(pyridin-3-yloxy)pyrrolidin-1-yl]quinazoline

SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cccnc3)c2cc1OC

InChI Key InChIKey=CMJKEYGSFOILJO-CQSZACIVSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14758   

LigandPNGBDBM14758((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Affinity DataKi:  128nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14758((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Affinity DataKi:  128nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14758((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Affinity DataKi:  302nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14758((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Affinity DataKi:  302nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14758((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Affinity DataKi:  748nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM14758((R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidi...)
Affinity DataKi:  748nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed