BDBM14771 (E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylidene}amino carbamate::Filaminast::[1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino] carbamate

SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O

InChI Key InChIKey=STTRYQAGHGJXJJ-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 14771   

LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  1.90E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase [574-941](Homo sapiens (Human))
Plexxikon

LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  8.90E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  9.40E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  960nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  1.00E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  960nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  990nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  1.20E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  2.70E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  5.70E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [531-875](Homo sapiens (Human))
Plexxikon

LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  5.30E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed