BDBM14826 1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(5-cyanopyrazin-2-yl)urea::3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea::Chk1_12::urea-based inhibitor 2a

SMILES Clc1ccc(OC2CCOC2)c(NC(=O)Nc2cnc(cn2)C#N)c1

InChI Key InChIKey=YPNTXIYIFCQOMG-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14826   

TargetSerine/threonine-protein kinase Chk1 [2-280](Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM14826(1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(...)
Affinity DataKi:  2.95nMAssay Description:33P-Radiometric_Method1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14826(1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14826(1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(...)
Affinity DataIC50:  3nMAssay Description:Abbott Kinase Enzymatics_CHK1/289 CDC25c - IC50(uM) (IC50)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14826(1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14826(1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(...)
Affinity DataIC50:  3nMAssay Description:ChemBL affinity - Published Abbott papersMore data for this Ligand-Target Pair
In DepthDetails PubMed