BDBM14952 5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide::5-[2-(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-[3-(trifluoromethyl)phenyl]benzamide::alkynylpyrimidine amide 6c

SMILES Nc1ncc(cn1)C#Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=YEVPZIUDTUZJGY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14952   

TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM14952(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3...)
Affinity DataIC50:  47nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck [245-498](Homo sapiens (Human))
Amgen

LigandPNGBDBM14952(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3...)
Affinity DataIC50:  65nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM14952(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3...)
Affinity DataIC50:  6nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed