BDBM149712 US8975409, Example 9

SMILES CC(C)CC1(O)CCN(CC1)C(=O)Nc1cc(Oc2ccc(F)cc2)cc(Oc2ccc(cc2)C(C)(C)C(O)=O)c1

InChI Key InChIKey=MBTKFRQXHPGCLC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 149712   

TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50:  2.30nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50:  2.5nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In DepthDetails US Patent