BDBM150835 US8981106, 24

SMILES OC(=O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1

InChI Key InChIKey=AXXQRZSDTMJHHP-UHFFFAOYSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 150835   

TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150835(US8981106, 24)
Show SMILES OC(=O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15FN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)
Affinity DataIC50: 1.48E+3nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150835(US8981106, 24)
Show SMILES OC(=O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15FN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)
Affinity DataIC50: 1.48E+3nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair