BDBM151212 US8987314, B3

SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(F)nc1

InChI Key InChIKey=CBLAEKNWNNMTOT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 151212   

TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM151212(US8987314, B3)
Affinity DataIC50: <10nMpH: 8.0 T: 2°CAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Mus musculus (Mouse))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM151212(US8987314, B3)
Affinity DataIC50:  200nMAssay Description:Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatic triacylglycerol lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM151212(US8987314, B3)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human hepatic lipase expressed in African green monkey COS7 cells using PED-A1 as substrate incubated for 20 mins and measured every 20...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM151212(US8987314, B3)
Affinity DataIC50:  5nMAssay Description:Inhibition of human endothelial lipase derived from human HT1080 cell conditioned media using PED-A1 as substrate incubated for 20 mins and measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed