BDBM15160 1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl]phenyl}methyl)piperidin-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one::CHEMBL362016::pyrazinone 13f

SMILES CC(C)Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1

InChI Key InChIKey=RPSREAHMBSYUSD-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15160   

TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM15160(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Affinity DataKi:  325nMAssay Description:Inhibition of Akt2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15160(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15160(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM15160(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Affinity DataIC50:  1.80E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed