BDBM15362 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethylbenzene-1,3-diol::CCT018159::CHEMBL399530::VER-00063579

SMILES CCc1cc(-c2n[nH]c(C)c2-c2ccc3OCCOc3c2)c(O)cc1O

InChI Key InChIKey=OWPMENVYXDJDOW-UHFFFAOYSA-N

Data  5 IC50  1 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15362   

TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15362(4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1...)
Affinity DataIC50:  280nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15362(4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1...)
Affinity DataIC50:  280nM EC50:  5.80E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetATP-dependent molecular chaperone HSP82(Saccharomyces cerevisiae)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15362(4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of yeast Hsp90 ATPase activityMore data for this Ligand-Target Pair
TargetATP-dependent molecular chaperone HSP82(Saccharomyces cerevisiae)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15362(4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of yeast Hsp90 ATPase activityMore data for this Ligand-Target Pair
TargetATP-dependent molecular chaperone HSP82(Saccharomyces cerevisiae)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15362(4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1...)
Affinity DataIC50:  8.90E+3nMAssay Description:Binding affinity to yeast Hsp90 ATPase activityMore data for this Ligand-Target Pair