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BDBM15431 1,3-dimethyl-5-[4-(2-methylphenyl)-2-(thiophen-2-yl)-1H-imidazol-5-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one::benzimidazolone 12q

SMILES: Cc1ccccc1-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1

InChI Key: InChIKey=LVGPEYZHETXGSJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15431   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM15431
PNG
(1,3-dimethyl-5-[4-(2-methylphenyl)-2-(thiophen-2-y...)
Show SMILES Cc1ccccc1-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C23H20N4OS/c1-14-7-4-5-8-16(14)21-20(24-22(25-21)19-9-6-12-29-19)15-10-11-17-18(13-15)27(3)23(28)26(17)2/h4-13H,1-3H3,(H,24,25)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 6.20E+3n/an/an/an/a7.230



Pfizer Inc



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair