BDBM158156 US10081622, Compound 26::US9029356, 26::US9255087, 26::US9616059, 26

SMILES COCCNc1cc(ccc1C(=O)Nc1n[nH]c2ccc(Cc3cc(F)cc(F)c3)cc12)N1CCN(C)CC1

InChI Key InChIKey=ICYGLDQWNJHCEE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 158156   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  411nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  1.10E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of IGF1R (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  1.76E+3nMAssay Description:Inhibition of IR (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US10081622, Compound 26 | US9029356, 26 | US925508...)
Affinity DataIC50:  568nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In DepthDetails US Patent