BDBM158481 US9029401, 1728 (t-TUCB)

SMILES OC(=O)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=XDVFKCZZXOGEMN-CZIWCDLHSA-N

Data  1 KI  20 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 158481   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataKi:  156nMAssay Description:Competitive inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using varying CMN...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant sEHMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  260nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  5.70nMAssay Description:Inhibition of soluble epoxide in mouse brain microsomes using CMNPC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of microsomal epoxide hydrolase (unknown origin) expressed in baculovirus system using CMNMC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  0.400nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  140nMAssay Description:Inhibition of human FAAH expressed in baculovirus-infected High Five cells S9 fraction using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/lactonase 3(Homo sapiens)
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PON3 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArylacetamide deacetylase(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AADAC (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Mus musculus (mouse))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of FAAH in mouse brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAAH in rat brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluo...More data for this Ligand-Target Pair
TargetLiver carboxylesterase 1(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human carboxylesterase 1 expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human carboxylesterase 2 expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 2(Homo sapiens)
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PON2 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  54nMAssay Description:Inhibition of soluble epoxide in rat brain microsomes using CMNPC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  1nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as fluorescent substrateMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50:  0.900nMAssay Description:See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Inhibitor Concentration at 50% enzyme inhibition (IC50) values were calculated by quantifying the end-point ADP production from each kinase reaction ...More data for this Ligand-Target Pair
In DepthDetails US Patent