BDBM160475 US10093663, Example 26b::US9682968, Example-26a

SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O

InChI Key

Data  8 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 160475   

TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50:  0.0100nMAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to human serine protease factor B by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50:  400nMAssay Description:Inhibition of human serine protease factor B in human PNH patient derived sample assessed as prevention of erythrocyte lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50:  130nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50:  110nMAssay Description:Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human AP protein factor DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160475(US10093663, Example 26b | US9682968, Example-26a)
Affinity DataIC50:  12nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed