BDBM16095 2-[(6-bromonaphthalene-2-)(methyl)amido]benzoic acid::2-{[(6-bromonaphthalen-2-yl)carbonyl](methyl)amino}benzoic acid::Inhibitor 3

SMILES CN(C(=O)c1ccc2cc(Br)ccc2c1)c1ccccc1C(O)=O

InChI Key InChIKey=BZTPIBLYAWWYLK-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16095   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Leeds

LigandPNGBDBM16095(2-[(6-bromonaphthalene-2-)(methyl)amido]benzoic ac...)
Affinity DataKi:  1.08E+4nM ΔG°:  -6.77kcal/mole IC50:  9.34E+4nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Leeds

LigandPNGBDBM16095(2-[(6-bromonaphthalene-2-)(methyl)amido]benzoic ac...)
Affinity DataIC50:  9.33E+4nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds

LigandPNGBDBM16095(2-[(6-bromonaphthalene-2-)(methyl)amido]benzoic ac...)
Affinity DataIC50: >2.00E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed