BDBM16096 2-[(6-bromonaphthalene-2-)amido]benzoic acid::2-{[(6-bromonaphthalen-2-yl)carbonyl]amino}benzoic acid::Inhibitor 4

SMILES OC(=O)c1ccccc1NC(=O)c1ccc2cc(Br)ccc2c1

InChI Key InChIKey=KNVPXLPBRSRJCV-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16096   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds

LigandPNGBDBM16096(2-[(6-bromonaphthalene-2-)amido]benzoic acid | 2-{...)
Affinity DataKi:  1.10E+3nM ΔG°:  -8.12kcal/mole IC50:  8.40E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Leeds

LigandPNGBDBM16096(2-[(6-bromonaphthalene-2-)amido]benzoic acid | 2-{...)
Affinity DataKi:  1.64E+4nM ΔG°:  -6.52kcal/mole IC50:  1.43E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Leeds

LigandPNGBDBM16096(2-[(6-bromonaphthalene-2-)amido]benzoic acid | 2-{...)
Affinity DataIC50:  1.41E+5nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In DepthDetails Article