BDBM161396 US10124003, Ex. Compound 9::US10835536, Ex. Comp 9::US10894048, Ex Comp 51::US9108973, 9

SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12

InChI Key InChIKey=GYXODBZTJVUDOH-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 161396   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  3.20nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  1.10nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  0.300nMAssay Description:Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  4.90nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  1.70nMAssay Description:The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50: <0.300nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  3.20nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  0.300nMAssay Description:The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  4.90nMAssay Description:The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  1.20nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  0.100nMAssay Description:The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161396(US10124003, Ex. Compound 9 | US10835536, Ex. Comp ...)
Affinity DataIC50:  1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent