BDBM161438 US10124003, Ex. Compound 51::US10835536, Ex. Comp 51::US9108973, 51

SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12

InChI Key InChIKey=CXJITJGGCTWHEG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 161438   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161438(US10124003, Ex. Compound 51 | US10835536, Ex. Comp...)
Affinity DataIC50:  1.20nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161438(US10124003, Ex. Compound 51 | US10835536, Ex. Comp...)
Affinity DataIC50: <0.300nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161438(US10124003, Ex. Compound 51 | US10835536, Ex. Comp...)
Affinity DataIC50: <0.300nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161438(US10124003, Ex. Compound 51 | US10835536, Ex. Comp...)
Affinity DataIC50:  1.70nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161438(US10124003, Ex. Compound 51 | US10835536, Ex. Comp...)
Affinity DataIC50: <0.300nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161438(US10124003, Ex. Compound 51 | US10835536, Ex. Comp...)
Affinity DataIC50:  0.100nMAssay Description:Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent