BDBM16272 2-({2-[(3R)-3-aminopiperidin-1-yl]-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile::Racemic::quinazolinone-based inhibitor 1a

SMILES N[C@@H]1CCCN(C1)c1nc2ccccc2c(=O)n1Cc1ccccc1C#N

InChI Key InChIKey=OYNURZXTLNNKAP-QGZVFWFLSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16272   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM16272(2-({2-[(3R)-3-aminopiperidin-1-yl]-4-oxo-3,4-dihyd...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM16272(2-({2-[(3R)-3-aminopiperidin-1-yl]-4-oxo-3,4-dihyd...)
Affinity DataIC50:  13nMAssay Description:Inhibition of dipeptidyl peptidase 4 (unknown origin)More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM16272(2-({2-[(3R)-3-aminopiperidin-1-yl]-4-oxo-3,4-dihyd...)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed