BDBM16312 (4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione::CHEMBL266497::Sorbinil
SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
InChI Key InChIKey=LXANPKRCLVQAOG-NSHDSACASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 84 hits for monomerid = 16312
Affinity DataIC50: 140nMpH: 7.0 T: 24°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetAldo-keto reductase family 1 member B1 [L301M](Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 500nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lensMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:The compound was tested for the inhibition of Aldose reductase in rat lens assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of aldose reductase from rat lens. Value ranges from 0.07 - 1.2More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human placental aldose reductase (HPAR) activity with glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against aldose reductase in rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:In vitro inhibition of rabbit lens aldose reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibitory activity of the compound was determined against human placental aldose reductase (HPAR) with glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Concentration required to produce 50% inhibition of aldose reductase enzyme (the literature IC50 value for sorbinil is 0.07 uM)More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against human placenta aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against bovine lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+3nMAssay Description:The compound was tested for Inhibitory effect against Aldose reductase 1 in bovine kidneysMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of aldose reductase in rat lens by spectrophotometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
Affinity DataIC50: 3.04E+3nMAssay Description:In vitro inhibitory activity against Aldose reductase 2 obtained from calf lensesMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Human)
Rational Drug Design Laboratories
Curated by ChEMBL
Rational Drug Design Laboratories
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Tested for in vitro inhibition activity against human aldehyde reductase (AHR)More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Tested for in vitro inhibition activity against rat Aldose reductase (AR)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Tested for in vitro inhibition activity against human Aldose reductase (human AR)More data for this Ligand-Target Pair
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyr...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity of compound against rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibitory concentration against rat ALR2 aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Human)
Rational Drug Design Laboratories
Curated by ChEMBL
Rational Drug Design Laboratories
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against human ALR2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Pig)
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of ALR2 in calf lenses using DL-glyceraldehyde as substrate treated with compound for 10 mins prior to substrate addition by UV spectropho...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductase in rat lensesMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reducti...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Human)
Rational Drug Design Laboratories
Curated by ChEMBL
Rational Drug Design Laboratories
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type)More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration against aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 3 hits for monomerid = 16312
ITC DataΔG°: -9.05kcal/mole logk: 4.50E+6
T: 24.85°C
T: 24.85°C
CellAldose Reductase (ALR2) Mutant (L300P)(Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
ITC DataΔG°: -9.24kcal/mole −TΔS°: 1.91kcal/mole ΔH°: -11.2kcal/mole logk: 6.10E+6
pH: 8.0 T: 24.85°C
pH: 8.0 T: 24.85°C
ITC DataΔG°: -9.05kcal/mole −TΔS°: 3.32kcal/mole ΔH°: -12.4kcal/mole logk: 4.50E+6
pH: 8.0 T: 24.85°C
pH: 8.0 T: 24.85°C