BDBM163970 US9062078, 101::US9475819, 101::US9637496, 101::US9695183, 101

SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2

InChI Key InChIKey=CSTPGELOUGJKMU-UHFFFAOYSA-N

Data  8 KI

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 163970   

TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  650nM ΔG°:  -7.84kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  650nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  650nM ΔG°:  -7.84kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  650nM ΔG°:  -8.86kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  1.20E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  1.20E+3nM ΔG°:  -8.48kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  1.20E+3nM ΔG°:  -8.48kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM163970(US9062078, 101 | US9475819, 101 | US9637496, 101 |...)
Show SMILES Cc1ccc(N2CCCC2)c(n1)C(=O)N1C2CCC1C(COc1ncc(F)cn1)C2
Show InChI InChI=1S/C22H26FN5O2/c1-14-4-6-19(27-8-2-3-9-27)20(26-14)21(29)28-17-5-7-18(28)15(10-17)13-30-22-24-11-16(23)12-25-22/h4,6,11-12,15,17-18H,2-3,5,7-10,13H2,1H3
Affinity DataKi:  1.20E+3nM ΔG°:  -8.48kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair