BDBM164140 BDBM255252::US9062078, 270::US9637496, 270::US9695183, 270

SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1

InChI Key InChIKey=BNPVELSULLCXLP-UHFFFAOYSA-N

Data  8 KI

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 164140   

TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  145nM ΔG°:  -9.79kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  145nM ΔG°:  -9.79kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  145nM ΔG°:  -9.79kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  145nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  325nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  325nM ΔG°:  -8.22kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  325nM ΔG°:  -9.29kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM164140(BDBM255252 | US9062078, 270 | US9637496, 270 | US9...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2nccn3c(Br)cnc23)c1-c1ncccn1
Show InChI InChI=1S/C23H19BrFN7O/c24-18-12-29-22-21(28-9-10-31(18)22)30-16-11-13-5-6-17(16)32(13)23(33)14-3-1-4-15(25)19(14)20-26-7-2-8-27-20/h1-4,7-10,12-13,16-17H,5-6,11H2,(H,28,30)
Affinity DataKi:  325nM ΔG°:  -8.22kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid