BDBM164901 US10166239, Ex. 3-15::US11406644, Example 3-15::US9067914, Ex. 3-15

SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1

InChI Key InChIKey=HVRWZFQFSQUILC-UHFFFAOYSA-N

Data  16 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 164901   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 2nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP-002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.300nMAssay Description:In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.100nMAssay Description:In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 2nMAssay Description:In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.300nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.100nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 2nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.300nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.100nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825 (end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) usin...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genzyme Corporation

US Patent
LigandPNGBDBM164901(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair