BindingDB logo
myBDB logout

BDBM16794 3-[(2S)-2-amino-3-phenylpropoxy]-5-{3-ethenyl-1H-pyrazolo[3,4-c]pyridin-5-yl}pyridine::pyrazolopyridine analog, 25a

SMILES: N[C@H](COc1cncc(c1)-c1cc2c(C=C)n[nH]c2cn1)Cc1ccccc1

InChI Key: InChIKey=QVZTZUQJFINWOX-KRWDZBQOSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16794   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16794
PNG
(3-[(2S)-2-amino-3-phenylpropoxy]-5-{3-ethenyl-1H-p...)
Show SMILES N[C@H](COc1cncc(c1)-c1cc2c(C=C)n[nH]c2cn1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5O/c1-2-20-19-10-21(25-13-22(19)27-26-20)16-9-18(12-24-11-16)28-14-17(23)8-15-6-4-3-5-7-15/h2-7,9-13,17H,1,8,14,23H2,(H,26,27)/t17-/m0/s1
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem 15: 2441-52 (2007)


Article DOI: 10.1016/j.bmc.2007.01.010
BindingDB Entry DOI: 10.7270/Q26Q1VGQ
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM16794
PNG
(3-[(2S)-2-amino-3-phenylpropoxy]-5-{3-ethenyl-1H-p...)
Show SMILES N[C@H](COc1cncc(c1)-c1cc2c(C=C)n[nH]c2cn1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5O/c1-2-20-19-10-21(25-13-22(19)27-26-20)16-9-18(12-24-11-16)28-14-17(23)8-15-6-4-3-5-7-15/h2-7,9-13,17H,1,8,14,23H2,(H,26,27)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM16794
PNG
(3-[(2S)-2-amino-3-phenylpropoxy]-5-{3-ethenyl-1H-p...)
Show SMILES N[C@H](COc1cncc(c1)-c1cc2c(C=C)n[nH]c2cn1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5O/c1-2-20-19-10-21(25-13-22(19)27-26-20)16-9-18(12-24-11-16)28-14-17(23)8-15-6-4-3-5-7-15/h2-7,9-13,17H,1,8,14,23H2,(H,26,27)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem 15: 2441-52 (2007)


Article DOI: 10.1016/j.bmc.2007.01.010
BindingDB Entry DOI: 10.7270/Q26Q1VGQ
More data for this
Ligand-Target Pair