BindingDB BDBM168223 US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3-methyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl]amino]pyrimidin-4-yl]cyclopropanecarboxamide (Cpd. No. 52)::US9669031, 87 6-[(6-aminopyrimidin-4-yl)amino]-8-chloro-3-(3-fluorophenyl)-3-methyl-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 87)

BDBM168223 US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3-methyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl]amino]pyrimidin-4-yl]cyclopropanecarboxamide (Cpd. No. 52)::US9669031, 87 6-[(6-aminopyrimidin-4-yl)amino]-8-chloro-3-(3-fluorophenyl)-3-methyl-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 87)

SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1

InChI Key InChIKey=BTPOGDUCUHHPDU-UHFFFAOYSA-N

Data 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168223

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent

BDBM168223(US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3...)

IC50: <10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details US Patent

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent