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BDBM168379 US9669031, 234 6-((6-amino-5-methoxypyrimidin-4-yl)amino)-8-methyl-1′-(2,2,2-trifluoroethyl)-2H-spiro[imidazo[1,5-a]pyridine-3,4′-piperidine]-1,5-dione (Cpd. No. 234)

SMILES: COc1c(NC(=O)C2CC2)ncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)(F)F)CC3)n2c1=O

InChI Key: InChIKey=SPKPCNAIFPZGHP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168379   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM168379
PNG
(US9669031, 234 6-((6-amino-5-methoxypyrimidin-4-yl...)
Show SMILES COc1c(NC(=O)C2CC2)ncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)(F)F)CC3)n2c1=O
Show InChI InChI=1S/C23H26F3N7O4/c1-12-9-14(29-17-16(37-2)18(28-11-27-17)30-19(34)13-3-4-13)21(36)33-15(12)20(35)31-22(33)5-7-32(8-6-22)10-23(24,25)26/h9,11,13H,3-8,10H2,1-2H3,(H,31,35)(H2,27,28,29,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR Therapeutics Inc

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair