BDBM17090 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(methylamino)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 10b::ZK 814048::ZK814048

SMILES CNCc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl

InChI Key InChIKey=CYFNXPSIQONWKY-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17090   

TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17090(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.210nM ΔG°:  -13.1kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Canis lupus familiaris (Dog))
Berlex Biosciences

LigandPNGBDBM17090(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  1.70nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Rattus norvegicus (rat))
Berlex Biosciences

LigandPNGBDBM17090(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  2.5nM ΔG°:  -11.6kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17090(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  3.70E+3nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

LigandPNGBDBM17090(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi: >1.00E+4nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed