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BDBM171216 US9085555, 646

SMILES: CC(=O)c1cn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cnc(C)cc12

InChI Key: InChIKey=XYFAQELYKFHVQT-HBGVWJBISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 171216   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor D


(Homo sapiens (Human))
BDBM171216
PNG
(US9085555, 646)
Show SMILES CC(=O)c1cn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cnc(C)cc12
Show InChI InChI=1S/C25H24ClFN4O3/c1-13-6-17-18(14(2)32)11-30(22(17)10-28-13)12-23(33)31-20-7-16(20)8-21(31)25(34)29-9-15-4-3-5-19(26)24(15)27/h3-6,10-11,16,20-21H,7-9,12H2,1-2H3,(H,29,34)/t16-,20-,21+/m1/s1
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Similars

US Patent
n/an/a 12n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...


US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair