BDBM17282 7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl-1H-1,3-benzodiazol-1-yl}methyl)naphthalene-2-carboximidamide::CHEMBL173020::Naphthylamidine template, I::ZK-806711

SMILES CC(=N)N1CCC(CC1)Oc1ccc2nc(C)n(Cc3ccc4ccc(cc4c3)C(N)=N)c2c1

InChI Key InChIKey=JABMRQOJSAZJAD-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17282   

TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  0.270nMAssay Description:In vitro inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  0.270nM ΔG°:  -12.9kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex

LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  18nM ΔG°:  -10.5kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Berlex

LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  18nMAssay Description:In vitro inhibitory activity against bovine cationic trypsinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  230nMAssay Description:In vitro inhibitory activity against human coagulation factor IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed