BDBM175153 US9115117, 55::US9611251, 55

SMILES CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C

InChI Key InChIKey=AJDWPJCBXKCGQC-RHSMWYFYSA-N

Data  4 KI

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 175153   

TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175153(US9115117, 55 | US9611251, 55)
Show SMILES CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C
Show InChI InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1
Affinity DataKi:  1.20E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175153(US9115117, 55 | US9611251, 55)
Show SMILES CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C
Show InChI InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1
Affinity DataKi:  1.20E+3nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor(Genebank accession number NM_001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175153(US9115117, 55 | US9611251, 55)
Show SMILES CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C
Show InChI InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1
Affinity DataKi: >1.00E+4nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175153(US9115117, 55 | US9611251, 55)
Show SMILES CCOc1ccccc1C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@H]1C
Show InChI InChI=1S/C21H24F3N3O2/c1-3-29-18-9-5-4-7-16(18)20(28)27-12-6-8-17(14(27)2)26-19-11-10-15(13-25-19)21(22,23)24/h4-5,7,9-11,13-14,17H,3,6,8,12H2,1-2H3,(H,25,26)/t14-,17-/m1/s1
Affinity DataKi: >1.00E+4nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession numberNM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022) , 10%...More data for this Ligand-Target Pair