BDBM175201 US9115117, 103::US9611251, 103

SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F

InChI Key InChIKey=FTQQHPMQVXWTDW-SUMWQHHRSA-N

Data  6 KI

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 175201   

TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175201(US9115117, 103 | US9611251, 103)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1
Affinity DataKi:  44nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor(Genebank accession number NM_001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175201(US9115117, 103 | US9611251, 103)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1
Affinity DataKi:  44nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175201(US9115117, 103 | US9611251, 103)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1
Affinity DataKi:  97nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175201(US9115117, 103 | US9611251, 103)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1
Affinity DataKi:  97nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor(Genebank accession number NM_001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175201(US9115117, 103 | US9611251, 103)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1
Affinity DataKi:  2.30E+3nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175201(US9115117, 103 | US9611251, 103)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N6O2/c1-13-17(31-19-24-11-14(12-25-19)20(21,22)23)7-4-10-28(13)18(30)15-5-2-3-6-16(15)29-26-8-9-27-29/h2-3,5-6,8-9,11-13,17H,4,7,10H2,1H3/t13-,17+/m0/s1
Affinity DataKi:  2.30E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession numberNM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022) , 10%...More data for this Ligand-Target Pair