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BDBM175290 N,N'-(biphenyl-4,4'-diyl)bis(N-(phenylsulfonyl)acetamide) (3a)

SMILES: CC(=O)N(c1ccc(cc1)-c1ccc(cc1)N(C(C)=O)S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1

InChI Key: InChIKey=VMYKTLMJXGNDDB-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 175290   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinesterases


(Homo sapiens (Human))
BDBM175290
PNG
(N,N'-(biphenyl-4,4'-diyl)bis(N-(phenylsulf...)
Show SMILES CC(=O)N(c1ccc(cc1)-c1ccc(cc1)N(C(C)=O)S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H24N2O6S2/c1-21(31)29(37(33,34)27-9-5-3-6-10-27)25-17-13-23(14-18-25)24-15-19-26(20-16-24)30(22(2)32)38(35,36)28-11-7-4-8-12-28/h3-20H,1-2H3
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.56E+5n/an/an/an/a7.7n/a



Government College University



Assay Description
The butyrylcholinesterase (BChE) inhibition activity was determined according to the Ellman's method with minor modifications. Total volume of th...


Bioorg Chem 64: 13-20 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.002
BindingDB Entry DOI: 10.7270/Q20V8BJK
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM175290
PNG
(N,N'-(biphenyl-4,4'-diyl)bis(N-(phenylsulf...)
Show SMILES CC(=O)N(c1ccc(cc1)-c1ccc(cc1)N(C(C)=O)S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H24N2O6S2/c1-21(31)29(37(33,34)27-9-5-3-6-10-27)25-17-13-23(14-18-25)24-15-19-26(20-16-24)30(22(2)32)38(35,36)28-11-7-4-8-12-28/h3-20H,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.03E+5n/an/an/an/a7.7n/a



Government College University



Assay Description
The AChE inhibition activity was determined according to the Ellman's method with slight modifications. Total volume of the reaction mixture was ...


Bioorg Chem 64: 13-20 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.002
BindingDB Entry DOI: 10.7270/Q20V8BJK
More data for this
Ligand-Target Pair