BDBM17594 A-357300::CHEMBL352764::N'-[(2S,3R)-3-amino-2-hydroxy-5-(propan-2-ylsulfanyl)pentanoyl]-3-chlorobenzohydrazide::bestatin-type inhibitor, 9

SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1

InChI Key InChIKey=BYBVYIPUGPZRSX-OLZOCXBDSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17594   

TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17594(A-357300 | CHEMBL352764 | N'-[(2S,3R)-3-amino-2-hy...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)23-7-6-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)8-10/h3-5,8-9,12-13,20H,6-7,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
Affinity DataIC50: 120nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17594(A-357300 | CHEMBL352764 | N'-[(2S,3R)-3-amino-2-hy...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)23-7-6-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)8-10/h3-5,8-9,12-13,20H,6-7,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
Affinity DataIC50: 5.70E+4nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17594(A-357300 | CHEMBL352764 | N'-[(2S,3R)-3-amino-2-hy...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)23-7-6-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)8-10/h3-5,8-9,12-13,20H,6-7,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human MetAP2 using Met-Ala-Ser as substrate measured at 20 secs interval for 20 mins by AAO/horse radish peroxidase enzyme ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17594(A-357300 | CHEMBL352764 | N'-[(2S,3R)-3-amino-2-hy...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)23-7-6-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)8-10/h3-5,8-9,12-13,20H,6-7,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against human methionine aminopeptidase-2More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17594(A-357300 | CHEMBL352764 | N'-[(2S,3R)-3-amino-2-hy...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)23-7-6-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)8-10/h3-5,8-9,12-13,20H,6-7,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibitory activity against human methionine aminopeptidase-1More data for this Ligand-Target Pair