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BDBM176336 US9688696, 51

SMILES: CCN(CC)CCCc1noc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl

InChI Key: InChIKey=FUZQIMUYZIPFKN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176336   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176336
PNG
(US9688696, 51)
Show SMILES CCN(CC)CCCc1noc(n1)-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H32Cl2N6O2/c1-3-32(4-2)14-6-9-23-29-25(36-31-23)19-10-12-20(13-11-19)33-15-17-34(18-16-33)26(35)30-24-21(27)7-5-8-22(24)28/h5,7-8,10-13H,3-4,6,9,14-18H2,1-2H3,(H,30,35)
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.02E+3n/an/an/an/a7.425



Janssen Pharmaceutica NV

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


US Patent US9688696 (2017)


BindingDB Entry DOI: 10.7270/Q24X55ZP
More data for this
Ligand-Target Pair