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BDBM176357 US9688696, 73

SMILES: FC(F)(F)c1ccccc1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CCCCC1

InChI Key: InChIKey=UGDBURZNYXKUDX-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176357   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM176357
PNG
(US9688696, 73)
Show SMILES FC(F)(F)c1ccccc1NC(=O)N1CCN(CC1)c1ccc(cc1)-c1noc(n1)C1CCCCC1
Show InChI InChI=1S/C26H28F3N5O2/c27-26(28,29)21-8-4-5-9-22(21)30-25(35)34-16-14-33(15-17-34)20-12-10-18(11-13-20)23-31-24(36-32-23)19-6-2-1-3-7-19/h4-5,8-13,19H,1-3,6-7,14-17H2,(H,30,35)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 912n/an/an/an/a7.425



Janssen Pharmaceutica NV

US Patent


Assay Description
DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...


US Patent US9688696 (2017)


BindingDB Entry DOI: 10.7270/Q24X55ZP
More data for this
Ligand-Target Pair