BDBM17739 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({3-fluoro-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]carbamate::2-aminopyrimidine carbamate, 38

SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCN4CCN(C)CC4)c(F)c3)n2)c(OC)c1

InChI Key InChIKey=CVTIVBFOLJQENW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17739   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM17739(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17739(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50:  570nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM17739(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50:  3.00E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

LigandPNGBDBM17739(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50:  6nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed