BDBM179803 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (11a)::US10053458, Comparative Example 1
SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
InChI Key InChIKey=KTEIFNKAUNYNJU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 179803
TargetIsoform 2 of Hepatocyte growth factor receptor (2)(Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 14.6nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...More data for this Ligand-Target Pair
3D Structure (crystal)TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 17.6nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [C1156Y](Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 133nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 337nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant GST-tagged wild type ALK (1064 to 1427 residues) (unknown origin) expressed in Sf9 cells using TMB peptide as substrate pre...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
East China University Of Science & Technology
Curated by ChEMBL
East China University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of human recombinant N-terminal hexahistidine tagged JAK2 JH1 catalytic domain (835 to 1132 residues) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant GST-tagged ALK L1196M mutant (1064 to 1427 residues) (unknown origin) expressed in Sf9 cells using TMB peptide as substrate...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 36nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair