BindingDB BDBM179879 US10231963, Table B.25::US10287250, Compound B.7::US10736890, Compound TABLE B.25::US10752592, Compound TABLE B.7::US11534436, Compound Table B.25::US9133125, Table B, Compound 7::US9656961, Example 00142

BDBM179879 US10231963, Table B.25::US10287250, Compound B.7::US10736890, Compound TABLE B.25::US10752592, Compound TABLE B.7::US11534436, Compound Table B.25::US9133125, Table B, Compound 7::US9656961, Example 00142

SMILES NC(=O)c1ccc2C[C@@H]3[C@@H]4CC[C@@H](O)C[C@]4(CCN3CC3CCC3)c2c1O

InChI Key InChIKey=BRYWNCYUZQAGMJ-WHEACTPUSA-N

Data 7 KI 7 IC50 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 179879

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

Ki: 0.130nM ΔG°: -13.5kcal/mole IC50: 3.70nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

Ki: 0.130nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

Ki: 0.130nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

Ki: 0.130nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

Ki: 0.130nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

Ki: 0.130nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

Ki: 0.130nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

IC50: 3.70nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

IC50: 3.70nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

EC50: 1.5nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

IC50: 3.70nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

IC50: 3.70nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

EC50: 1.5nMpH: 7.4Assay Description:The EC50 and Imax for μ opioid receptors was determined using a [I35S]GTPγS binding assay. This assay measures the functional properties of a compo...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

IC50: 3.70nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

IC50: 3.70nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

EC50: 1.5nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

EC50: 1.5nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Mu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent

PNG

BDBM179879(US10231963, Table B.25 | US10287250, Compound B.7 ...)

EC50: 1.5nMAssay Description:The EC50 and Imax for μ opioid receptors was determined using a [35S]GTPγS binding assay. This assay measures the functional properties of ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent