BDBM180270 US9133162, Example 1

SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C

InChI Key InChIKey=VQYYQSZNRVQLIS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 180270   

TargetHepatocyte growth factor receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50:  19nMpH: 7.0 T: 25°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHepatocyte growth factor receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50:  68nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase receptor UFO(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50:  11nMpH: 7.0 T: 25°CAssay Description:Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetVascular endothelial growth factor receptor 2(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50:  37nMpH: 7.0 T: 25°CAssay Description:KDR (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM MgAcetate and [γ-33P-ATP] (specific activity app...More data for this Ligand-Target Pair
In DepthDetails US Patent