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BDBM184474 US9150578, I-108

SMILES: Cn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(CCN6CCOCC6)c5)c4-c3n2)n1

InChI Key: InChIKey=PTPQXKBVULYOLN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 184474   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor 1 receptor (aa 964-1370)


(Homo sapiens (Human))
BDBM184474
PNG
(US9150578, I-108)
Show SMILES Cn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(CCN6CCOCC6)c5)c4-c3n2)n1
Show InChI InChI=1S/C30H34N10O/c1-37-9-8-27(36-37)33-30-31-18-23-6-7-25-28(29(23)34-30)26(38(2)35-25)17-21-4-3-5-22(16-21)24-19-32-40(20-24)11-10-39-12-14-41-15-13-39/h3-5,8-9,16,18-20H,6-7,10-15,17H2,1-2H3,(H,31,33,34,36)
PDB

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PC cid
PC sid
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Similars

US Patent
n/an/a 0.480n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair