BDBM18524 6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one::CHEMBL436784::LGD2226

SMILES FC(F)(F)CN(CC(F)(F)F)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F

InChI Key InChIKey=ULBPQWIGZUGPHU-UHFFFAOYSA-N

Data  4 KI  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 18524   

TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  1nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity at androgen receptor (unknown origin)More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  4.60nM ΔG°:  -11.8kcal/mole EC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataEC50:  0.200nMAssay Description:Modulation of Androgen receptor (unknown origin)More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human Androgen receptorMore data for this Ligand-Target Pair