BDBM185355 US9156831, 6

SMILES C[C@H](CO)C(=O)N1CCC(CC1)c1nc(-c2cnc(N)c(n2)-c2nnc(o2)C(C)(C)C)n(C)n1

InChI Key InChIKey=LOLDQPMMGNHKHJ-GFCCVEGCSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 185355   

LigandPNGBDBM185355(US9156831, 6)
Affinity DataIC50:  32nMT: 2°CAssay Description:The inhibition of PI3K-beta, PI3K-alpha, PI3K-gamma and PI3K-delta was evaluated in a Kinase Glo based enzyme activity assay using human recombinant ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM185355(US9156831, 6)
Affinity DataIC50: <12nMT: 2°CAssay Description:The inhibition of PI3K-beta, PI3K-alpha, PI3K-gamma and PI3K-delta was evaluated in a Kinase Glo based enzyme activity assay using human recombinant ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM185355(US9156831, 6)
Affinity DataIC50: >3.00E+4nMAssay Description:ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM185355(US9156831, 6)
Affinity DataIC50:  530nMT: 2°CAssay Description:This assay was used to measure PI3K-alpha inhibition in cells. BT474 cells (human breast ductal carcinoma, ATCC HTB-20) were seeded into black 384 we...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM185355(US9156831, 6)
Affinity DataIC50:  3.42E+3nMT: 2°CAssay Description:The inhibition of PI3K-beta, PI3K-alpha, PI3K-gamma and PI3K-delta was evaluated in a Kinase Glo based enzyme activity assay using human recombinant ...More data for this Ligand-Target Pair
In DepthDetails US Patent